Zeptol® CR

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Zeptol® CR is an anticonvulsant and mood stabilizer in the form of prolonged-release tablets. Zeptol® CR is used for epilepsy-associated seizures, manic-depressive disorder, management of alcohol withdrawal symptoms, and paroxysmal pain caused by neuralgia among other health conditions. Suitable for patients over 5 years of age.

Active Ingredient:
Carbamazepine

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Zeptol® CR, 400mg pills

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Zeptol® CR, 300mg pills

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General Info

Description

Zeptol® CR is manufactured by Sun Pharmaceutical Industries. The active ingredient of these prolonged-release tablets is Carbamazepine, anticonvulsant structurally similar to tricyclic antidepressants.

Indications:

- management of epilepsy characterized by generalized tonic-clonic and partial seizures (do not confuse with absence or myoclonic seizures);

- paroxysmal (suddenly occurring) pain associated with trigeminal neuralgia, peripheral diabetic neuropathy, glossopharyngeal neuralgia, tabetic lightning pain, superior laryngeal neuralgia, stump pain, phantom limb pain, and post herpetic neuralgia;

- management of alcohol withdrawal symptoms;

- treatment and prophylaxis of mania and manic-depressive disorder (also known as bipolar disorder). Suitable for patients unresponsive to lithium.

Zeptol® CR is also used to decrease the urinary volume in patients with diabetes insipidus (do not confuse with diabetes mellitus or sugar diabetes) because of its antidiuretic effect.

MOA (mechanism of action):

Carbamazepine is a complex drug possessing anticonvulsant, anticholinergic, antidiuretic, antiarrhythmic, muscle relaxant, antidepressant, sedative, and neuromuscular-blocking properties. Carbamazepine acts by balancing the electrical activity in the brain and nerves. By these actions, Carbamazepine stops the built up of electrical signals in the brain and releases neurotransmitters (nerve-exciting agent), thereby preventing the occurrence of seizures. In patients suffering from neurology and other pain-causing disorders, Carbamazepine is thought to stopping the pain signals being sent to the brain. It also thought to reduce the glutamate activity in the brain, therefore having a mood stabilizing effect.

Dosage

Zeptol® CR tablets should be swallowed whole and taken with a full glass of water.

The exact dosage, as well as the course duration, must be determined by a doctor for each individual patient.

Zeptol® CR tablets are only for oral use.

Patients of Han Chinese or Thai origin should be blood tested before starting the Zeptol® CR treatment course.

Do not give Zeptol® CR to patients under 5 years of age.

Do not change your usual dosage suddenly or without your doctor’s approval.

Women taking oral contraceptives containing oestrogen and/or progesterone should use alternative forms of contraception during the Zeptol® CR treatment course.

Epilepsy:

The usual starting dose for adults varies from 100 to 200 mg once or twice daily. The average adult dose varies from 800 to 1200 mg daily in divided intakes.

The average daily dose for children between 5 and 10 years of age varies from 400 to 600 mg daily in divided intakes.

The average daily dose for children between 10 and 17 years of age varies from 600 to 1000 mg in divided intakes.

Paroxysmal pain:

The usual starting dose for adults varies from 200 to 400 mg once or twice daily. The average adult dose varies from 600 to 800 mg daily in divided intakes.

The usual starting dose for elderly patients is 100 mg twice daily. The average geriatric dose varies from 600 to 800 mg daily in divided intakes.

The average daily dose for children between 5 and 10 years of age varies from 400 to 600 mg daily in divided intakes.

The average daily dose for children between 10 and 17 years of age varies from 600 to 1000 mg in divided intakes.

The daily dose should be slowly reduced by your doctor once the remission is achieved.

The maximum recommended dose is 1200 mg a day.

Manic-depressive disorder:

The usual starting dose is 400 mg daily in divided intakes.

The average recommended dose varies from 400 to 600 mg daily in divided intakes. Depending on patient’s response the dose should be slowly increased until the symptoms are controlled.

The maximum recommended dose is 1600 mg daily.

Missing a dose

If you miss a dose you should take it as soon as you remember about your missing. If it is the time for the next dose you should continue your regular dosing schedule. Do not take a double dose.

Overdose

If an overdose occurs and you are not feeling well, stop taking the medication immediately. You should seek emergency medical attention or contact your healthcare provider immediately.

Storage

Store at room temperature between 10 and 25 degrees C and away from excess moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Safety Information

Side effects

The most common side effects associated with the use of Zeptol® CR are:

  • low white cell count (leucopenia) causing more infections than usual
  • severe peeling of the skin
  • difficulty breathing
  • wheezing and coughing
  • allergic reactions
  • fever
  • skin rash
  • abnormalities in blood and liver function tests
  • joint, muscle or chest pain
  • systemic lupus erythematosus
  • yellowing of your skin or the whites of your eyes
  • dizziness or tiredness
  • difficulty controlling movements
  • nausea
  • fluid retention
  • weight gain
  • headache
  • confusion
  • blurred vision
  • dry mouth
  • headache

Side effects occurrence does not only depend on the medication you are taking, but also on your overall health and other factors.

Contraindications

Do not take Zeptol® CR if you are allergic to Carbamazepine.

Do not take Zeptol® CR if you are allergic to any of the other ingredients comprised in Zeptol® CR.

Do not take Zeptol® CR if you have a heart disorder, problems with your bone marrow, porphyria, liver or kidney disease, low sodium blood level, alcoholism, difficulty to retain your urine, mental illness, mixed or absence seizures, blood disorders including leucopenia.

Do not take Zeptol® CR if you have ever interrupted courses of treatment with Carbamazepine.

The use of Zeptol® CR may affect the therapeutic effect of oral contraceptive drugs containing oestrogen and/or progesterone.

Do not consume alcohol, grapefruits and grapefruit juice while taking Zeptol® CR.

Do not combine Zeptol® CR with the use of other antiepileptics (lamotrigine, phenytoin, fosphenytoin, primidone, sodium valproate, phenobarbitone, ethosuximide, oxcarbazepine, tiagabine, topiramate, vigabatrin, levetiracetam, progabide), anticoagulants (warfarin, acenocoumarol), stomach ulcers medications (cimetidine, omeprazole), antipsychotics (lithium, haloperidol, thioridazine, olanzapine, risperidone, clozapine, quetiapine), schizophrenia drugs (paliperidone, aripiprazole), sedatives (lobazam, clonazepam, alprazolam, valnoctamide), antidepressants (imipramine, fluoxetine, amitriptyline, clomipramine, nortriptyline, mianserin, sertraline, paroxteine, fluvoxamine, citalopram, trazodone), St John’s wort preparation, sickness treatments (metoclopramide, aprepitant), antibiotics (doxycycline, isoniazid, erythromycin, clarithromycin, ciprofloxacin), tuberculosis medications (isoniazid, rifampicin), antifungals (itraconazole, fluconazole, ketoconazole, voriconazole, albendazole), corticosteroids (prednisolone, dexamethasone), immunosuppressants (ciclosporin, tacrolimus, sirolimus), painkillers (paracetamol, dextropropoxyphene, methadone, tramadol, buprenorphine), heart medications (felodipine, isradipine, digoxin, verapamil, diltiazem), diuretics (furosemide, hydrochlorothiazide), glaucoma drugs (acetazolamide), muscle relaxants (pancuronium), retinoids (isotretinoin), asthma drugs (theophylline, aminophylline), endometriosis medications (danazol, gestrinone), Hormone Replacement Therapy (tibolone), impotence drugs (tadalafil), cancer treatments (imatinib, lapatinib, toremifene, cisplatin, doxorubicin, temsirolimus, cyclophosphamide), malaria medications (mefloquine), HIV drugs also known as protease inhibitors (indinavir, ritonavir, saquinavir), hypothyroidism grugs (levothyroxine), anti-smoking agents (bupropion), antihistamines (loratadine), and Vitamin B supplements.

Do not give Zeptol® CR to children under 5 years of age.

It is recommended not to use Zeptol® CR in pregnant and breastfeeding women.

Do not drive or operate machinery as Zeptol® CR causes dizziness.

F.A.Q.

Q: What is Zeptol® CR used for?

A: Zeptol® CR is an anticonvulsant and mood stabilizer in the form of prolonged-release tablets. Zeptol® CR is used for epilepsy-associated seizures, manic-depressive disorder, management of alcohol withdrawal symptoms, and paroxysmal pain caused by neuralgia among other health conditions.

Q: Is Zeptol® CR save?

A: Zeptol® CR is safe for patients over 5 years of age as long as used for prescribed conditions and at prescribed doses.

Q: Can pregnant women use Zeptol® CR?

A: It is recommended not to use Zeptol® CR in pregnant and breastfeeding women.

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